Regional Brain Tissue Changes and Associations with Disease Severity in Children with Sleep Disordered Breathing
Sleep, zsx203, https://doi.org/10.1093/sleep/zsx203 Published: 15 December 2017 | Academic.oup.com Abstract Study Objectives Children with sleep-disordered breathing (SDB) exhibit behavioral, cognitive, and autonomic deficits, suggestive of neural injury. We assessed whether the tissue alterations resulted from acute or chronic processes, and if alterations correlated with disease severity. Methods Brain tissue integrity was examined with mean diffusivity (MD) (3.0-Tesla scanner) in 20 non-snoring controls (mean age±sem, 12.2±0.6y; 10 male) and 18 children with SDB (12.3±0.7y; 11 male). Sleep, cognitive, and behavioral measures were compared between groups following overnight polysomnography using Student’s t-tests. Whole-brain MD maps were realigned and averaged, normalized, smoothed, and compared …
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